Antihypertensive Drug Therapy in Saskatchewan

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Appraisal of antihypertensive drug therapy.

SUMMARY Four completed prospective studies of drug-treated and control hypertensives utilizing double blind ran-domized protocols are reviewed for the purpose of evaluating the evidence on which the present therapeutic crusade is based. Patients studied were predominantly male, observed for short period, had complications or died at young age, had high incidence of previous target organ vascula...

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Rebuttal: appraisal of antihypertensive drug therapy.

DR. HERBERT CHASIS has long been known for his skepticism with respect to the treatment of hypertension. Indeed, it was the skepticism of Drs. Goldring, Chasis and Perera which served as an important stimulus in planning the Veterans Administration Cooperative Study. Dr. Chasis completely rejects the concept that the cardiovascular damage seen in hypertension is the consequence of the elevated ...

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Systematic review: antihypertensive drug therapy in black patients.

BACKGROUND Hypertension occurs more frequently and is generally more severe in black persons than in white persons, leading to excess morbidity and mortality. PURPOSE To systematically review the efficacy of different antihypertensive drugs in reducing blood pressure, morbidity, and mortality in hypertensive black adults. DATA SOURCES The following databases were searched from their incepti...

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Antihypertensive drug therapy prevents cerebral microvascular abnormalities in hypertensive rats.

Studies were performed on anesthetized 16-18 week old normotensive Wistar-Kyoto rats, spontaneously hypertensive rats, and Goldblatt two-kidney one clip renal hypertensive rats, treated from age 4-5 weeks with an oral antihypertensive regimen consisting of hydralazine, reserpine, and chlorothiazide. Measurements of flow and intravascular pressure in the cerebral microvasculature were made via a...

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Antihypertensive Drug Therapy in Consideration of Circadian Blood Pressure Variation*

J-MUBA was a large-scale clinical study which, for the first time in the world, evaluated the effects of an antihypertensive drug on circadian BP variation in more than 600 patients with hypertension. Although ACE inhibitors reportedly exert equal 24-hour antihypertensive effects on daytime and nighttime BP, and -blockers are reported to have weaker effects on nighttime BP than on daytime BP. H...

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ژورنال

عنوان ژورنال: Archives of Internal Medicine

سال: 2001

ISSN: 0003-9926

DOI: 10.1001/archinte.161.15.1873